Michael Cooley's Genetic Genealogy Blog GEN • GEN
14 May 2016

Y-STRs and Genetic Distance


DYS
393
DYS
390
DYS
19
DYS
391
DYS
385a
DYS
385b
DYS
426
DYS
388
DYS
439
DYS
389i
DYS
458
DYS
389ii
13 25 14 10 11 13 12 12 12 13 14 29
12-Marker Y-STRs

Any man who has tested his Y chromosome has certainly looked at something like the above. I say man because only men have a Y chromosome (it carries the male sex gene) and they inherit it only from their fathers. Because there is no female sex gene, a woman is a woman because she lacks the Y. A mother, therefore, cannot pass a Y chromosome from her father to her descendants because she can't "carry" it in the first place. It's as simple as that. Although other chromosomes "marry," the Y doesn't. Perhaps one might say it's an eternal bachelor because it has nothing with which to pair. This bachelor "reproduces" itself by cloning then passing the copy down to the father's sons—generation after generation. This means a man's Y looks like his paternal 6th great-grandfather's Y. It is the same Y, even if it gets modified a bit every few generations. Due to naming conventions, it follows the surname.

The chart above is an example of Short Tandem Repeats (STRs). They're just that: short strings of DNA that are repeated in tandem to one another n number of times. For example, strings of TCTA appear in the Y chromosome at position DYS391 (column 4). In this case, they repeat 10 times.




Genetic Distance

Here we compare two testers by determining their genetic distance:


DYS
393
DYS
390
DYS
19
DYS
391
DYS
385a
DYS
385b
DYS
426
DYS
388
DYS
439
DYS
389i
DYS
458
DYS
389ii
13 24 15 11 11 13 12 12 10 13 11 30
14 23 15 10 14 15 11 13 11 14 12 32
1 1 0 1 3 2 1 1 1 1 1 2
Total Genetic Distance = 15

Using simple subtraction, find the difference between the paired values and write down the grand total grand total. This example has a genetic distance of 15 out of 12 markers. What does that mean? For testers to be of the same family, they should have a genetic distance no greater than 1 out of 12 markers. But even that can be misleading. Many of us match with people across several geographic regions and surnames. Often, a 12-marker match will fall apart once 37 markers are tested. The Cooley DNA Project requests that members order 37 markers. Some admins prefer to see 67 markers.

The upshot is that even if the two men represented above had the same surname, they're not related.